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Expression of PPAR is also found in hypothalamic nuclei that govern energy metabolism 24 , and viral-mediated overexpression of hypothalamic PPAR decreases food intake in diet-induced obese (DIO) mice 25
In mice, a high-fat diet has also been shown to impair leptin signaling by attenuating STAT3 activation, thus contributing to leptin resistance [18].Leptin receptor activation engages intracellular proteins, such as protein tyrosine phosphatase1 B (PTP1B) and suppressor of cytokine signaling-3, that terminate receptor signaling
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Some types of blurry vision also resolve without treatment
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